ABSTRACT
The multi-drug resistance phenomena can limit the effect of chemnotherapy and lead to the recurrence of leukemia. One of the main mechanisms of multi drug resistance is the increased expression of MDRl gene that codes P-gp, a Tran's membrane carrier that exports drugs out of the leukemic cells. The aim of the study was to explore the effect of resveratrol, a natural compound, on the expression of MDRl gene in leukemic cell line MOLT-4. MTT [Methyl Tiazol Tetrazolium] assay was used to determine the sub toxic of resveratrol for treatment of leukemic cells line real Time PCR was used to determine the expression of MDRl gene. MOLT-4 cell line resistance was assessed after MTT implementation. Resveratrol could not suppress the growth of MOLT-4 cells. Genetic studies revealed increased expression of MDRl gene. Resistance of MOLT-4 cells to vincristine was increased after coadministration of vincristine and resveratrol. We did not find evidence that resveratrol can reverse multi drug resistance in MOLT4 cells